Your browser doesn't support javascript.
loading
Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries
ANTUNES, Lívia Azeredo Alves; FIALHO, Walter; FERNANDES, Thais de Oliveira; DUARTE, Camila; TAVARES, Jhenyfer da Silva; KÜCHLER, Erika Calvano; ANTUNES, Leonardo Santos.
  • ANTUNES, Lívia Azeredo Alves; Universidade Federal Fluminense. School of Dentistry. Postgraduate Program in Dentistry. Niterói. BR
  • FIALHO, Walter; Universidade Federal Fluminense. School of Dentistry. Postgraduate Program in Dentistry. Niterói. BR
  • FERNANDES, Thais de Oliveira; Universidade Federal Fluminense. School of Dentistry. Department of Specific Formation. Nova Friburgo. BR
  • DUARTE, Camila; Universidade Federal Fluminense. School of Biomedicine. Clinical Research Unit. Niterói. BR
  • TAVARES, Jhenyfer da Silva; Universidade Federal Fluminense. School of Biomedicine. Clinical Research Unit. Niterói. BR
  • KÜCHLER, Erika Calvano; University of Regensburg. Department of Orthodontics. Regensburg. DE
  • ANTUNES, Leonardo Santos; Universidade Federal Fluminense. School of Dentistry. Postgraduate Program in Dentistry. Niterói. BR
Braz. oral res. (Online) ; 37: e076, 2023. tab, graf
Article Dans Anglais | LILACS-Express | LILACS, BBO | ID: biblio-1447727
ABSTRACT
Abstract This study aimed to assess whether genetic polymorphisms in MTR and MTRR are potential biomarkers of oral health-related quality of life (OHRQoL) in children with caries. A cross-sectional study was designed wherein pairs of parents/caregivers and children (aged two-five years) were selected. Clinical examination was used to detect dental caries, which were classified as low-severity and high-severity caries. The Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire was used to assess OHRQoL. Genomic DNA extracted from the saliva was used to analyze two missense genetic polymorphisms MTR (rs1805087) and MTRR (rs1801394). Mann-Whitney non-parametric test was used to analyze candidate genes with OHRQoL scale and domain, with a significance level of p≤0.05. MTR (rs1805087) was found associated (p = 0.05) with children's OHRQoL subscale scores in the dominant model (GG + AG). Genetic polymorphisms in MTR may increase the risk of poor OHRQoL in children with caries. Further studies are needed to investigate genetics, molecular factors, and OHRQoL.


Texte intégral: Disponible Indice: LILAS (Amériques) Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque langue: Anglais Texte intégral: Braz. oral res. (Online) Thème du journal: Dentisterie Année: 2023 Type: Article / descriptif de projet Pays d'affiliation: Brésil / Allemagne Institution/Pays d'affiliation: Universidade Federal Fluminense/BR / University of Regensburg/DE

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS


Texte intégral: Disponible Indice: LILAS (Amériques) Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque langue: Anglais Texte intégral: Braz. oral res. (Online) Thème du journal: Dentisterie Année: 2023 Type: Article / descriptif de projet Pays d'affiliation: Brésil / Allemagne Institution/Pays d'affiliation: Universidade Federal Fluminense/BR / University of Regensburg/DE