Systemic effects induced by intralesional injection of ?-conotoxin MVIIC after spinal cord injury in rats
J. venom. anim. toxins incl. trop. dis
;
20: 1-6, 04/02/2014. tab, graf, ilus
Article
Dans Anglais
| LILACS, VETINDEX
| ID: biblio-1484561
ABSTRACT
Calcium channel blockers such as conotoxins have shown a great potential to reduce brain and spinal cord injury. MVIIC neuroprotective effects analyzed in in vitro models of brain and spinal cord ischemia suggest a potential role of this toxin in preventing injury after spinal cord trauma. However, previous clinical studies with MVIIC demonstrated that clinical side effects might limit the usefulness of this drug and there is no research on its systemic effects. Therefore, the present study aimed to investigate the potential toxic effects of MVIIC on organs and to evaluate clinical and blood profiles of rats submitted to spinal cord injury and treated with this marine toxin. Rats were treated with placebo or MVIIC (at doses of 15, 30, 60 or 120 pmol) intralesionally following spinal cord injury. Seven days after the toxin administration, kidney, brain, lung, heart, liver, adrenal, muscles, pancreas, spleen, stomach, and intestine were histopathologically investigated. In addition, blood samples collected from the rats were tested for any hematologic or biochemical changes.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Plaies et blessures
/
Moelle osseuse
/
Inhibiteurs des canaux calciques
/
Conotoxines
/
Cerveau
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
J. venom. anim. toxins incl. trop. dis
Année:
2014
Type:
Article
Institution/Pays d'affiliation:
Universidade Federal de Minas Gerais/BR
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