Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinson's Disease
Rev. invest. clín
;
75(4): 193-202, Jul.-Aug. 2023. tab, graf
Article
Dans Anglais
|
LILACS-Express
| LILACS
| ID: biblio-1515323
ABSTRACT
ABSTRACT Background:
In Parkinson's disease (PD), exosomes carry α-synuclein (α-syn), a fibrillar protein aggregates with potential value as a biomarker.Objective:
Evidence on blood levels of exosomal α-syn in PD patients and controls was reviewed for their consistency.Methods:
Thirty-six studies on exosomal α-syn concentrations in PD were identified in a systematic literature search and meta-analysis.Results:
Both raw and ratio-adjusted blood exosomal α-syn levels were consistently higher in PD patients than in controls. The standardized mean difference (SMD) was 1.54 (0.18-2.90, CI95%, p < 0.01) and 1.53 (0.23-2.83, CI95%, p < 0.01), respectively.Conclusion:
Our results suggest that exosomal α-syn concentrations could be a useful biomarker for PD.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Type d'étude:
Revues systématiques évaluées
langue:
Anglais
Texte intégral:
Rev. invest. clín
Thème du journal:
Médicament
Année:
2023
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Mexique
Institution/Pays d'affiliation:
Instituto de Investigaciones Biomédicas/MX
/
Universidad Nacional Autónoma de México/MX
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