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Protective Effects of Curcumin Against Formaldehyde-induced Renal Toxicity in Rats
Sener, U; Uygur, R; Kurt, O; Caglar, V; Gelincik, I; Gurel, A; Erdogan, H.
Affiliation
  • Sener, U; Namik Kemal University. Department of Physiology. Tekirdag. TR
  • Uygur, R; Namik Kemal University. Department of Anatomy. Tekirdag. TR
  • Kurt, O; Namik Kemal University. Department of Urology. Tekirdag. TR
  • Caglar, V; Namik Kemal University. Department of Anatomy. Tekirdag. TR
  • Gelincik, I; Namik Kemal University. Department of Pathology. Tekirdag. TR
  • Gurel, A; Namik Kemal University. Faculty of Medicine. Department of Biochemistry. Tekirdag. TR
  • Erdogan, H; Namik Kemal University. Department of Physiology. Tekirdag. TR
West Indian med. j ; West Indian med. j;69(5): 338-344, 2021. tab, graf
Article de En | LILACS-Express | LILACS | ID: biblio-1515669
Bibliothèque responsable: BR1.1
ABSTRACT
ABSTRACT

Objective:

To explore the protective effects of curcumin against renal injury induced by formaldehyde in rats.

Methods:

A total of 21 male Sprague-Dawley rats were included. The animals were divided into three groups. The control group received 10 ml/kg of physiological saline intragastrically and intraperitoneally on a daily basis. The formaldehyde group were given 10 ml/kg of physiological saline intragastrically plus 10 mg/kg of formaldehyde intraperitoneally. The formaldehyde + curcumin group received 10 mg/kg of intraperitoneal formaldehyde daily as well as 100 mg/kg of curcumin intragastrically. After the completion of 14 days, the kidneys were removed. Tissue microscopic examination was performed with haematoxylin-eosin and periodic acid-Schiff staining. Also, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) activities, and malondialdehyde (MDA) and nitric oxide (NO) levels were measured in tissue samples.

Results:

Formaldehyde induced renal injury. The degenerative tissue changes in the formal-dehyde + curcumin group seemed to regress, exhibiting similar characteristics to those of the controls. MDA, XO and NO were significantly higher in formaldehyde group than in controls, while a significant reduction occurred in SOD, CAT and GSH-Px activities in the formaldehyde group. Also, renal tissue MDA, XO and NO were significantly lower in the formaldehyde + curcumin group than in the formaldehyde group, while tissue SOD, CAT and GSH-Px activities were significantly higher.

Conclusion:

Curcumin improved the formaldehyde-induced renal degeneration. Also, curcumin was found to prevent the reduction in SOD, CAT and GSH-Px activities, while preventing MDA, XO and NO levels, exhibiting a protective effect against the formaldehyde-induced oxidative renal injury.
Mots clés

Texte intégral: 1 Indice: LILACS langue: En Texte intégral: West Indian med. j Thème du journal: MEDICINA Année: 2021 Type: Article

Texte intégral: 1 Indice: LILACS langue: En Texte intégral: West Indian med. j Thème du journal: MEDICINA Année: 2021 Type: Article