Your browser doesn't support javascript.
loading
Study of long non-coding RNA Tug 1 expression in Egyptian colorectal adenocarcinoma patients
Amin, Yasmine; Ketat, Amel; Kamal, Hanan; Zaki, Inass; Moaz, Ahmed; Ghazala, Rasha Abdelmawla.
Affiliation
  • Amin, Yasmine; Alexandria University. Faculty of Medicine. Medical Biochemistry Department. Alexandria. EG
  • Ketat, Amel; Alexandria University. Faculty of Medicine. Medical Biochemistry Department. Alexandria. EG
  • Kamal, Hanan; Alexandria University. Faculty of Medicine. Medical Biochemistry Department. Alexandria. EG
  • Zaki, Inass; Alexandria University. Faculty of Medicine. Pathology Department. Alexandria. EG
  • Moaz, Ahmed; Alexandria University. Faculty of Medicine. Colorectal Surgery Department. Alexandria. EG
  • Ghazala, Rasha Abdelmawla; Alexandria University. Faculty of Medicine. Medical Biochemistry Department. Alexandria. EG
J. coloproctol. (Rio J., Impr.) ; 43(3): 166-170, July-sept. 2023. tab, graf, ilus
Article de En | LILACS | ID: biblio-1521148
Bibliothèque responsable: BR545.3
ABSTRACT

Purpose:

Colorectal cancer (CRC) is one of the most fatal tumors worldwide. In Egypt, most CRC cases occur in individuals > 40 years old. TUG1 has been proved to be disrupted in different malignancies and may have a critical role in tumor progression, invasion, and metastasis. However, its role in CRC has not been adequately studied. Materials /

Methods:

Quantitative real-time polymerase chain reaction (PCR) was used to evaluate the expression levels of long non-coding RNA (LncRNA) taurine upregulated gene 1 (TUG1), in nonmetastatic and metastatic CRC tissues and adjacent noncancerous tissues as control.

Results:

LncRNA TUG1 expression was significantly upregulated in both nonmetastatic and metastatic CRC tissues, in comparison with the adjacent noncancerous tissue. It was found that TUG1 could have a possible prognostic role in CRC, by comparing the sensitivity and specificity of TUG1 with those of CEA and CA19-9.

Conclusion:

The results of the current study suggest that the LncRNA TUG1 participates in the malignant behaviors of CRC cells. (AU)
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: Adénocarcinome / RT-PCR / ARN long non codant Limites du sujet: Adult / Aged / Aged80 / Female / Humans / Male langue: En Texte intégral: J. coloproctol. (Rio J., Impr.) Thème du journal: Cirurgia / Doen‡as Retais / Doen‡as do Colo / GASTROENTEROLOGIA / Cirurgia Année: 2023 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Adénocarcinome / RT-PCR / ARN long non codant Limites du sujet: Adult / Aged / Aged80 / Female / Humans / Male langue: En Texte intégral: J. coloproctol. (Rio J., Impr.) Thème du journal: Cirurgia / Doen‡as Retais / Doen‡as do Colo / GASTROENTEROLOGIA / Cirurgia Année: 2023 Type: Article