Effects of chronic restraint stress in the prostate of prepubertal and adult rats
Acta cir. bras
;
38: e387123, 2023. tab, ilus
Article
Dans Anglais
| LILACS, VETINDEX
| ID: biblio-1527594
ABSTRACT
Purpose:
To investigate the effects of chronic stress in the prostate of prepubertal and adult rats.Methods:
Thirty-two male rats were assigned into four groups depending on the type of treatment (control or stressed) and the age at which stress was initiated (prepubertal or adult). Restraint stress stimuli were applied for six weeks. Stressed prepubertal and adult rats evaluated immediately after the last stress stimuli were named SP and SA groups, respectively. Age-matched rats were used as control groups (CP and CA). At the end of the experiment, the rats were euthanized, and prostate morphological parameters were evaluated and statistically compared.Results:
Application of stress stimuli to the SP group resulted in reduced body weight, but no prostate morphological modification was noted. The SA group showed reduced testosterone level and prostatic epithelium surface density, in comparison to CA group. Further, the prostatic lumen surface density was increased in adult stressed animals, in comparison to adult controls.Conclusions:
The stress stimuli promoted changes in hormonal and morphological parameters in the prostate of adult stressed rats. Prepubertal stressed animals did not presented modifications of prostate morphology.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Prostate
/
Testostérone
/
Poids
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2023
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual do Rio de Janeiro/BR
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