Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components
J. venom. anim. toxins incl. trop. dis
;
30: e20230046, 2024. tab, ilus
Article
Dans Anglais
| LILACS, VETINDEX
| ID: biblio-1528980
ABSTRACT
Tityus serrulatus scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While supportive care is the primary treatment modality, moderate and severe cases require antivenom administration despite potential limitations and adverse effects. The remarkable proliferation of T. serrulatus scorpions, attributed to their biology and asexual reproduction, contributes to a high incidence of envenomation. T. serrulatus scorpion venom predominantly consists of short proteins acting as neurotoxins (α and ß), that primarily target ion channels. Nevertheless, high molecular weight compounds, including metalloproteases, serine proteases, phospholipases, and hyaluronidases, are also present in the venom. These compounds play a crucial role in envenomation, influencing the severity of symptoms and the spread of venom. This review endeavors to comprehensively understand the T. serrulatus scorpion venom by elucidating the primary high molecular weight compounds and exploring their potential contributions to envenomation. Understanding these compounds' mechanisms of action can aid in developing more effective treatments and prevention strategies, ultimately mitigating the impact of scorpion envenomation on public health in Brazil.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Venins de scorpion
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
J. venom. anim. toxins incl. trop. dis
Thème du journal:
Toxicologie
Année:
2024
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Amazonas State University/BR
/
Federal University of Roraima/BR
/
São Paulo State University/BR
/
University of São Paulo/BR
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