Embryo development is impaired by sperm mitochondrial-derived ROS
Biol. Res
;
57: 5-5, 2024. ilus, graf
Article
Dans Anglais
| LILACS
| ID: biblio-1550060
ABSTRACT
BACKGROUND:
Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pathways underlying these events still need to be elucidated, reactive oxygen species (ROS) could have a relevant role. We, therefore, aimed to describe the mechanisms through which mitochondrial activity can influence the first stages of embryo development.RESULTS:
We first show that embryo development is tightly influenced by both intracellular ROS and mitochondrial activity. In addition, we depict that the inhibition of mitochondrial activity dramatically decreases intracellular ROS levels. Finally, we also demonstrate that the inhibition of mitochondrial respiration positively influences sperm DNA integrity, most likely because of the depletion of intracellular ROS formation.CONCLUSION:
Collectively, the data presented in this work reveals that impairment of early embryo development may result from the accumulation of sperm DNA damage caused by mitochondrial-derived ROS.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Sperme
/
Mitochondries
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Biol. Res
Thème du journal:
Biologie
Année:
2024
Type:
Article
Pays d'affiliation:
Espagne
Institution/Pays d'affiliation:
University of Girona/ES
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS