An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus
J. venom. anim. toxins incl. trop. dis
;
30: e20230063, 2024. tab, graf
Article
Dans Anglais
| LILACS, VETINDEX
| ID: biblio-1550522
ABSTRACT
Background:
In Colombia, several species of Buthidae scorpions belonging to the genera Centruroides and Tityus coexist, and their stings are considered life-threatening to humans because of their venom neurotoxins. Despite previous studies focusing on neurotoxins from these scorpion genera, little is known about the enzymes present in their venoms and their relationship with whole venom toxicity.Methods:
Here, using proteomic and biochemical protocols the enzymatic activities of the venoms of three Colombian scorpion species, C. margaritatus, T. pachyurus, and T. n. sp. aff. metuendus, were compared to establish the presence and absence of enzymes such as phospholipases, hyaluronidases, and proteases that could be related to venom toxicity.Results:
C. margaritatus was positive for hyaluronidases, T. n. sp. aff. metuendus for proteases, and T. pachyurus exhibited activity for all three mentioned enzymes.Conclusion:
This information provides valuable insights into the specific enzyme diversity of each species' venom and their potential role in venom toxicity, which could contribute to the development of better treatments and prevention strategies for scorpion envenomation.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Venins de scorpion
Pays comme sujet:
Amérique du Sud
/
Colombie
langue:
Anglais
Texte intégral:
J. venom. anim. toxins incl. trop. dis
Thème du journal:
Toxicologie
Année:
2024
Type:
Article
Pays d'affiliation:
Colombie
/
Mexique
Institution/Pays d'affiliation:
Universidad Nacional Autónoma de México/MX
/
Universidad Tecnológica de Pereira/CO
/
Universidad del Cauca/CO
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