ENAM gene polymorphisms associated with dental anomalies in individuals with cleft lip and palate
Braz. j. oral sci
;
23: e241330, 2024. tab
Article
Dans Anglais
| LILACS, BBO
| ID: biblio-1553491
ABSTRACT
Aim:
This study aimed to investigate the occurrence of enamelin gene (ENAM) single nucleotide polymorphisms (SNP) and ENAM polymorphism association with dental anomalies (DA) in individuals with unilateral or bilateral cleft lip and palate (CLP).Methods:
Saliva samples were collected from 147 individuals aged between 6 and 15 years-old, both genders, and divided into 4 groups Group 1 (G1) - CLP and DA; Group 2 (G2) - CLP without DA; Group 3 (G3) - without CLP with DA; Group 4 (G4) - without CLP and DA. The genomic DNA was extracted from saliva samples and the following ENAM SNPs markers were genotyped rs3796703, rs3796704, rs3796705, rs7671281, rs2609428, and rs35951442. Fisher exact and Pearson's Chi-square tests statistically analyzed the results (α=5%).Results:
Individuals without CLP with DA (Group 3 - 19.2%) showed statistically higher prevalence of SNP rs2609428 heterozygotes (p=0.006) than individuals with CLP and DA (Group 1 - 0%). Individuals without CLP (10%) exhibited statistically higher prevalence of mutated heterozygotes/homozygous (p=0.028) than in individuals with CLP (1.3%).Conclusion:
SNP rs2609428 marker of ENAM gene may be associated with dental anomalies in individuals without cleft lip and palateSujets)
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Malformations dentaires
/
Protéines de la matrice extracellulaire
/
Bec-de-lièvre
/
Fente palatine
/
Polymorphisme de nucléotide simple
Limites du sujet:
Adolescent
/
Enfant
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. j. oral sci
Thème du journal:
Dentisterie
Année:
2024
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
University of São Paulo/BR
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