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Progesterone receptor B over progesterone receptor A prevents recurrence in bilateral endometriomas
Aslan, Ozgur; Yildiz, Sukru; Kaya, Cihan; Altinay, Serdar; Aydiner, Ilke Esin; Karabulut, Esra; Ekin, Murat; Yasar, Levent.
Affiliation
  • Aslan, Ozgur; Muş State Hospital. Department of Obstetrics and Gynecology. Muş. TR
  • Yildiz, Sukru; University of Health Sciences Turkey. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. Department of Obstetrics and Gynecology. İstanbul. TR
  • Kaya, Cihan; Acibadem Mehmet Ali Aydinlar University. Acibadem Bakirkoy Hospital. Department of Obstetrics and Gynecology. İstanbul. TR
  • Altinay, Serdar; University of Health Sciences Turkey. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. Department of Pathology. İstanbul. TR
  • Aydiner, Ilke Esin; University of Health Sciences Turkey. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. Department of Obstetrics and Gynecology. İstanbul. TR
  • Karabulut, Esra; University of Health Sciences Turkey. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. Department of Pathology. İstanbul. TR
  • Ekin, Murat; University of Health Sciences Turkey. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. Department of Obstetrics and Gynecology. İstanbul. TR
  • Yasar, Levent; University of Health Sciences Turkey. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. Department of Obstetrics and Gynecology. İstanbul. TR
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);70(9): e20240485, 2024. tab
Article de En | LILACS-Express | LILACS | ID: biblio-1575557
Bibliothèque responsable: BR1.1
ABSTRACT
SUMMARY

OBJECTIVE:

Endometriosis is a disease in which stromal cells and endometrial glands extend outside of the uterine cavity. Nevertheless, treatment failure and recurrence cause difficulties in management. This study aimed to evaluate the receptor-level components of bilateral endometriomas in the recurrence state.

METHODS:

Our retrospective cohort study was conducted with patients who underwent surgery for bilateral endometriomas between 2015 and 2021. In total, 113 patients were allocated. A total of 76 patients did not meet the eligibility criteria, and the data of 37 patients were evaluated. Medical treatments, recurrences, and postoperative follow-up data were collected. In archived tissue samples, measurements of progesterone receptor A and progesterone receptor B, histoscores and immunoreactivity scores, and their ratios were calculated in the group that received no postoperative medical treatment. Criteria for recurrence were a repeat operation and/or the detection of a new endometrioma>2 cm at the follow-up examination.

RESULTS:

No recurrence was observed in 73.0% (n=27) of the cases, whereas recurrence was observed in 27.0% (n=10) of the participants. Patients without recurrence had significantly higher progesterone receptor B histoscore/progesterone receptor A histoscore and progesterone receptor B immunoreactivity score/progesterone receptor A immunoreactivity score results (p=0.01). Nevertheless, when the histoscores and immunoreactivity scores for both receptors were contrasted separately, there was no appreciable difference between them.

CONCLUSION:

The dominance of progesterone receptor B over progesterone receptor A was inversely proportional to the recurrence status in bilateral endometriomas. Furthermore, our study revealed that assessing receptor levels alone did not result in a significant difference in recurrence.
Mots clés

Texte intégral: 1 Indice: LILACS langue: En Texte intégral: Rev. Assoc. Med. Bras. (1992, Impr.) Thème du journal: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Année: 2024 Type: Article / Project document

Texte intégral: 1 Indice: LILACS langue: En Texte intégral: Rev. Assoc. Med. Bras. (1992, Impr.) Thème du journal: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Année: 2024 Type: Article / Project document