In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients
Clin. biomed. res
; 37(1): 33-37, 2017. tab, graf
Article
Dans En
| LILACS
| ID: biblio-833278
Responsable en Bibliothèque :
BR18.1
Localisation: BR18.1
ABSTRACT
Introduction:
Recent evidence shows that oxidative stress seems to be related with the pathophysiology of X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder.Methods:
In the present study, the in vitro effect of N-acetyl-L-cysteine (NAC) on glutathione (GSH) and sulfhydryl levels in X-ALD patients was evaluated.Results:
A significant reduction of GSH and sulfhydryl content was observed in X-ALD patients compared to the control group. Furthermore, 5 mM of NAC, in vitro, led to an increase in GSH content and sulfhydryl groups in these patients.Conclusion:
These data probably indicate that an adjuvant therapy with the antioxidant NAC could improve the oxidative imbalance in X-ALD patients(AU)
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Acétylcystéine
/
Thiols
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Adrénoleucodystrophie
/
Glutathion
Limites du sujet:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
langue:
En
Texte intégral:
Clin. biomed. res
Thème du journal:
MEDICINA
Année:
2017
Type:
Article