A new index to discriminate between iron deficiency anemia and thalassemia trait
Rev. bras. hematol. hemoter
;
38(3): 214-219, 2016. gráfico, tabela, figura
Article
Dans Anglais
| LILACS
| ID: biblio-836770
ABSTRACT
BACKGROUND:
The most common microcytic and hypochromic anemias are iron deficiency anemia and thalassemia trait. Several indices to discriminate iron deficiency anemia from thalassemia trait have been proposed as simple diagnostic tools. However, some of the best discriminative indices use parameters in the formulas that are only measured in modern counters and are not always available in small laboratories. The development of an index with good diagnostic accuracy based only on parameters derived from the blood cell count obtained using simple counters would be useful in the clinical routine. Thus, the aim of this study was to develop and validate a discriminative index to differentiate iron deficiency anemia from thalassemia trait.METHODS:
To develop and to validate the new formula, blood count data from 106 (thalassemia trait 23 and iron deficiency 83) and 185 patients (thalassemia trait 30 and iron deficiency 155) were used, respectively. Iron deficiency, ß-thalassemia trait and a-thalassemia trait were confirmed by gold standard tests (low serum ferritin for iron deficiency anemia, HbA2 > 3.5% for ß-thalassemia trait and using molecular biology for the a-thalassemia trait).RESULTS:
The sensitivity, specificity, efficiency, Youden's Index, area under receiver operating characteristic curve and Kappa coefficient of the new formula, called the Matos & Carvalho Index were 99.3%, 76.7%, 95.7%, 76.0, 0.95 and 0.83, respectively.CONCLUSION:
The performance of this index was excellent with the advantage of being solely dependent on the mean corpuscular hemoglobin concentration and red blood cell count obtained from simple automatic counters and thus may be of great value in underdeveloped and developing countries.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Trait drépanocytaire
/
Thalassémie
/
Anémie par carence en fer
Type d'étude:
Étude pronostique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Rev. bras. hematol. hemoter
Thème du journal:
Hématologie
Année:
2016
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Hospital Odilon Behrens/BR
/
Instituto Federal de Minas Gerais/BR
/
Universidade Federal de Minas Gerais/BR
/
Universidade Federal de Ouro Preto/BR
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