The role of intradermal proliferation of T-cells in the pathogenesis of psoriasis
An. bras. dermatol
;
92(1): 41-44, Jan.-Feb. 2017. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-838026
ABSTRACT
Abstract BACKGROUND:
Psoriasis is a common immune-mediated chronic inflammatory disease of the skin and joints, affecting 1-3% of the population. It is generally accepted that the pathogenesis of psoriasis involves accumulation of effector T-cells within lymph nodes and their subsequent migration into the skin through the blood system. Here we provide evidence that psoriatic plaque itself may serve as a source of inflammatory T-cells.OBJECTIVE:
We examined the intradermal proliferation of T-cells and the number of effector/memory (CD45RO+) T-cells in the skin of psoriatic patients at different periods of the disease.METHODS:
Skin samples were obtained from 41 patients with progressive psoriatic lesions; 18 of these patients also donated skin specimens during the remission of the disease. The control group consisted of 16 healthy subjects. Ki-67 immunohistochemical staining was applied to detect proliferating cells, CD3ε served as a T-cell marker, and CD45RA and CD45RO antibodies were utilized to discriminate between naive and effector/memory T-cells, respectively.RESULTS:
Progressive psoriatic lesions demonstrated Ki67 staining both in keratinocytes and in the CD3ε+ cells of dermal infiltrate. Median count of CD45RO+ cells per microscopic field was 15 in healthy controls, 59 in patients in remission and 208 in progressive psoriatic plaques. The observed differences demonstrated high level of statistical significance. STUDYLIMITATIONS:
Limited number of analyzed patients.CONCLUSION:
Progressive phase of psoriasis is characterized by intradermal proliferation of T-cells. Spots of regressed psoriatic lesions contain high number of CD45RO+ cells, which are likely to render an immunological memory.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Psoriasis
/
Lymphocytes T
/
Prolifération cellulaire
/
Épiderme
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
Limites du sujet:
Adulte
/
Humains
langue:
Anglais
Texte intégral:
An. bras. dermatol
Thème du journal:
Dermatologie
Année:
2017
Type:
Article
Pays d'affiliation:
Russie
Institution/Pays d'affiliation:
SM Kirov Military Medical Academy/RU
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS