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A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma
Viana, Ana Carolina Leite; Goulart, Eugênio Marcos Andrade; Gontijo, Bernardo; Bittencourt, Flávia Vasques.
  • Viana, Ana Carolina Leite; Universidade Federal de Minas Gerais. Hospital das Clinicas. Dermatology Unity. Belo Horizonte. BR
  • Goulart, Eugênio Marcos Andrade; Universidade Federal de Minas Gerais. Hospital das Clinicas. Dermatology Unity. Belo Horizonte. BR
  • Gontijo, Bernardo; Universidade Federal de Minas Gerais. Hospital das Clinicas. Dermatology Unity. Belo Horizonte. BR
  • Bittencourt, Flávia Vasques; Universidade Federal de Minas Gerais. Hospital das Clinicas. Dermatology Unity. Belo Horizonte. BR
An. bras. dermatol ; 92(2): 200-205, Mar.-Apr. 2017. tab, graf
Article Dans Anglais | LILACS | ID: biblio-838037
ABSTRACT
Abstract

Background:

Large congenital melanocytic nevus (LCMN) is considered a risk factor for melanoma, although the magnitude of this risk is controversial.

Objective:

To evaluate the risk of melanoma development in patients with LCMN seen at a dermatology referral center in Brazil during a twelve-year period. To the best of our knowledge, there are no published similar studies on large congenital melanocytic nevus in South America.

Methods:

Our prospective cohort included only patients with congenital nevi ≥20cm. The cumulative risk of developing melanoma and the standardized morbidity ratio were calculated for patients followed up prospectively for at least 1 month.

Results:

Sixty-three patients were enrolled in this study. One patient who developed melanoma prior to enrollment was excluded, and five were eliminated because of insufficient follow-up time. Mean follow-up for the remaining 57 patients was 5.5 years (median 5.2 years). Median age of entry into the study was 2.6 years. Most patients (75.4%) underwent only clinical observation. Melanomas occurred in 2 (3.5%) patients. Five-year cumulative risk for melanoma was 4.8% (95% CI 1.9-11.5%). Standardized morbidity ratio was 1584 (95% CI 266-5232, p<0.001). Study

limitations:

The small sample size reduces the accuracy of risk estimates.

Conclusions:

This study analyzed prospectively for the first time data from South America demonstrating that patients with LCMN have a higher risk of developing melanoma than the general population (p<0.001).
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Tumeurs cutanées / Mélanome / Naevus pigmentaire Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Adulte / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Bébé / Mâle langue: Anglais Texte intégral: An. bras. dermatol Thème du journal: Dermatologie Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de Minas Gerais/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Tumeurs cutanées / Mélanome / Naevus pigmentaire Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Adulte / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Bébé / Mâle langue: Anglais Texte intégral: An. bras. dermatol Thème du journal: Dermatologie Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de Minas Gerais/BR