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Predictors of HBeAg seroconversion after long-term nucleos(t)ide analogues treatment for chronic hepatitis B: a multicenter study in real clinical setting
Yu, Weiyan; Wang, Yadong; Shen, Chuan; Ji, Ru; Zhang, Li; Zhao, Xin; Su, Miao; Zhang, Ying; He, Wenyan; Cao, Jianguo; Hao, Yanshuang; Chen, Shengpeng; Zhao, Caiyan.
  • Yu, Weiyan; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Wang, Yadong; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Shen, Chuan; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Ji, Ru; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Zhang, Li; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Zhao, Xin; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Su, Miao; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Zhang, Ying; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • He, Wenyan; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Cao, Jianguo; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Hao, Yanshuang; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Chen, Shengpeng; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
  • Zhao, Caiyan; Hebei Medical University. The Third Affiliated Hospital. Department of Infectious Diseases. Shijiazhuang. CN
Braz. j. infect. dis ; 21(3): 213-218, May-June 2017. tab, graf
Article Dans Anglais | LILACS | ID: biblio-839216
ABSTRACT
ABSTRACT

Aims:

To evaluate the HBeAg seroconversion rate in real clinical setting and explore its predictors in long-term nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B (CHB).

Methods:

251 patients were recruited from January 2001 to September 2009 in four hospitals in Hebei province, China, for this retrospective study. Clinical and laboratory data before and after treatment with lamivudine (LAM, 100 mg daily), adefovir (ADV, 10 mg daily), telbivudine (LDT, 600 mg daily), entecavir (ETV, 0.5 mg daily), and LAM/ADV combination were compared among three groups according to treatment

outcomes:

synchronous HBeAg loss and HBeAg seroconversion, anti-HBe development after treatment, and no anti-HBe. Adherence was also evaluated.

Results:

In real clinical setting, cumulative HBeAg seroconversion rates were 14.3%, 32.7%, 43.0%, 46.9%, and 50.5% after 1, 2, 3, 5, and 8 years, respectively. 45 patients (17.9%) were non-adherent. Adherence (p < 0.001, Hazard Ratio (HR) = 2.203), elevated alanine aminotransferase (ALT) levels (p < 0.001, HR = 2.049), and non-vertical transmission (p = 0.006, HR = 1.656) were predictors of HBeAg seroconversion.

Conclusion:

Adherence, elevated ALT, and non-vertical transmission are predictors of HBeAg seroconversion in CHB patients treated with NAs.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Antiviraux / Hépatite B chronique / Antigènes e du virus de l&apos;hépatite virale B Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains / Mâle langue: Anglais Texte intégral: Braz. j. infect. dis Thème du journal: Maladies transmissibles Année: 2017 Type: Article Pays d'affiliation: Chine Institution/Pays d'affiliation: Hebei Medical University/CN

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Antiviraux / Hépatite B chronique / Antigènes e du virus de l&apos;hépatite virale B Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains / Mâle langue: Anglais Texte intégral: Braz. j. infect. dis Thème du journal: Maladies transmissibles Année: 2017 Type: Article Pays d'affiliation: Chine Institution/Pays d'affiliation: Hebei Medical University/CN