Presence of t(14; 18) translocation in healthy individuals varies according to ethnic background in the Brazilian population

Levy, D; Bertoldi, ERM; Ruiz, JLM; Pereira, J; Bydlowski, SP

Levy, D; Bertoldi, ERM; Ruiz, JLM; Pereira, J; Bydlowski, SP.

Levy, D; Universidade de São Paulo. Faculdade de Medicina. Laboratório de Genética e Hematologia Molecular (LIM31). São Paulo. BR
Bertoldi, ERM; Universidade de São Paulo. Faculdade de Medicina. Laboratório de Genética e Hematologia Molecular (LIM31). São Paulo. BR
Ruiz, JLM; Universidade de São Paulo. Faculdade de Medicina. Laboratório de Genética e Hematologia Molecular (LIM31). São Paulo. BR
Pereira, J; Universidade de São Paulo. Faculdade de Medicina. Laboratório de Genética e Hematologia Molecular (LIM31). São Paulo. BR
Bydlowski, SP; Universidade de São Paulo. Faculdade de Medicina. Laboratório de Genética e Hematologia Molecular (LIM31). São Paulo. BR

Braz. j. med. biol. res ; 50(7): e6172, 2017. tab, graf

Article Dans Anglais | LILACS | ID: biblio-839317

ABSTRACT

ABSTRACT

Several groups have demonstrated that healthy individuals can present the t(14;18) translocation. In this report, the presence of the translocation was examined in healthy blood donors in Brazil, a country considered an ethnic melting pot. The translocation was detected by nested PCR in 227 peripheral blood samples from individuals with different ethnic backgrounds. The t(14;18) translocation was found in 45 of 85 White individuals (52.94%); in 57 of 72 Black individuals (79.17%); and in 68 of 70 individuals (97.14%) of Japanese-descent. In conclusion, the frequency of the t(14;18) translocation in the Brazilian population varies according to the ethnic background.

Sujets)

Characterization; Lymphomas; Molecular genetics; T(14;18)

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Translocation génétique / Chromosomes humains de la paire 14 / Chromosomes humains de la paire 18 / Lymphome folliculaire Limites du sujet: Adolescent / Adulte / Adulte très âgé / Femelle / Humains / Mâle Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de São Paulo/BR

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