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New evidences on the regulation of SF-1 expression by POD1/TCF21 in adrenocortical tumor cells
França, Monica Malheiros; Lerario, Antonio M; Fragoso, Maria Candida BV; Lotfi, Claudimara Ferini Pacicco.
  • França, Monica Malheiros; Universidade de São Paulo. Departamento de Anatomia. Instituto de Ciencias Biomedicas. Sao Paulo. BR
  • Lerario, Antonio M; Universidade de São Paulo. Departamento de Anatomia. Instituto de Ciencias Biomedicas. Sao Paulo. BR
  • Fragoso, Maria Candida BV; Universidade de São Paulo. Departamento de Anatomia. Instituto de Ciencias Biomedicas. Sao Paulo. BR
  • Lotfi, Claudimara Ferini Pacicco; Universidade de São Paulo. Departamento de Anatomia. Instituto de Ciencias Biomedicas. Sao Paulo. BR
Clinics ; 72(6): 391-394, June 2017. graf
Article Dans Anglais | LILACS | ID: biblio-840089
ABSTRACT

OBJECTIVES:

Transcription Factor 21 represses steroidogenic factor 1, a nuclear receptor required for gonadal development, sex determination and the regulation of adrenogonadal steroidogenesis. The aim of this study was to investigate whether silencing or overexpression of the gene Transcription Factor 21 could modulate the gene and protein expression of steroidogenic factor 1 in adrenocortical tumors.

METHODS:

We analyzed the gene expression of steroidogenic factor 1 using qPCR after silencing endogenous Transcription Factor 21 in pediatric adrenal adenoma-T7 cells through small interfering RNA. In addition, using overexpression of Transcription Factor 21 in human adrenocortical carcinoma cells, we analyzed the protein expression of steroidogenic factor 1 using Western blotting.

RESULTS:

Transcription Factor 21 knockdown increased the mRNA expression of steroidogenic factor 1 by 5.97-fold in pediatric adrenal adenoma-T7 cells. Additionally, Transcription Factor 21 overexpression inhibited the protein expression of steroidogenic factor 1 by 0.41-fold and 0.64-fold in two different adult adrenocortical carcinoma cell cultures, H295R and T36, respectively.

CONCLUSIONS:

Transcription Factor 21 is downregulated in adrenocortical carcinoma cells. Taken together, these findings support the hypothesis that Transcription Factor 21 is a regulator of steroidogenic factor 1 and is a tumor suppressor gene in pediatric and adult adrenocortical tumors.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Régulation de l'expression des gènes tumoraux / Tumeurs corticosurrénaliennes / Facteurs de transcription à motif basique hélice-boucle-hélice / Facteur stéroïdogène-1 Limites du sujet: Humains langue: Anglais Texte intégral: Clinics Thème du journal: Médicament Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de São Paulo/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Régulation de l'expression des gènes tumoraux / Tumeurs corticosurrénaliennes / Facteurs de transcription à motif basique hélice-boucle-hélice / Facteur stéroïdogène-1 Limites du sujet: Humains langue: Anglais Texte intégral: Clinics Thème du journal: Médicament Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de São Paulo/BR