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Association of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis patients using fixed-dose combination therapy in Contagem, Minas Gerais, Brazil
Viegas, Ana Maria; Miranda, Silvana Spíndola de; Haddad, João Paulo; Ceccato, Maria das Graças; Carvalho, Wânia da Silva.
  • Viegas, Ana Maria; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte. BR
  • Miranda, Silvana Spíndola de; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte. BR
  • Haddad, João Paulo; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte. BR
  • Ceccato, Maria das Graças; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte. BR
  • Carvalho, Wânia da Silva; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte. BR
Rev. Inst. Med. Trop. Säo Paulo ; 59: e28, 2017. tab, graf
Article Dans Anglais | LILACS | ID: biblio-842784
ABSTRACT
ABSTRACT The present study aimed to assess the association of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis (TB) patients using fixed-dose combination (FDC) therapy in the city of Contagem, MG, Brazil. This study used standardized questionnaires to collect data. Outcomes included cure in 77.2% (64/ 83), noncompliance with treatment in 20.4% (17/ 83), and absence of organ failure or death cases. The rate of adherence to treatment was high (71.1% - 59/ 83), while the level of comprehension of the treatment was insufficient for the majority of patients (72.3% - 60/ 83). When a greater number of medicines was used, the chance of noncompliance with treatment increased exponentially (p = 0.00 - OR 1.72). Light-skinned black patients, alcoholics and those who live with HIV/ AIDS showed a significant association with noncompliance with treatment (p=0.039 - OR 3.38, p=0.002 - OR 4.68, and p=0.001 - OR 9.68, respectively). Comprehension also presented a significant association with noncompliance with treatment (p=0.01 and OR 5.76 and CI 1.49-22.29). The probability of noncompliance with treatment in the first few months was greater than in the subsequent months. This study demonstrates that if the TB patients had a better understanding of the treatment, the outcome would have been more favorable as regards a proper cure.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Tuberculose / Observance par le patient / Antituberculeux Type d'étude: Étude observationnelle / Facteurs de risque Limites du sujet: Adolescent / Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Rev. Inst. Med. Trop. Säo Paulo Thème du journal: Médecine tropicale Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de Minas Gerais/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Tuberculose / Observance par le patient / Antituberculeux Type d'étude: Étude observationnelle / Facteurs de risque Limites du sujet: Adolescent / Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Rev. Inst. Med. Trop. Säo Paulo Thème du journal: Médecine tropicale Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de Minas Gerais/BR