Neoplasia de células dendríticas plasmocitoides blásticas con respuesta inicial a quimioterapia y recaída en sistema nervioso central: caso clínico / Blastic plasmacytoid dendritic cell neoplasm with complete clinical remission with chemotherapy and central nervous system relapse: report of one case
Rev. méd. Chile
;
145(1): 115-120, ene. 2017. ilus, graf, tab
Article
Dans Espagnol
| LILACS
| ID: biblio-845510
ABSTRACT
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, clinically aggressive hematologic malignancy that most commonly manifests as cutaneous lesions with or without bone marrow involvement and leukemic dissemination. The demonstration of tumor cells with the characteristic immunophenotype with expression of CD56, generally CD4 and dendritic cell antigens (CD123, cyTCL-1, HLA-DR), in the absence of myeloid or lymphoid lineage markers is required for the diagnosis. Responses to chemotherapy are initially satisfactory, with frequent systemic and central nervous system relapses. We report a 24 year-old male with BPDCN, initially diagnosed and treated as non-Hodgkin CD4+ T-cell lymphoma, with initial complete remission who evolved with early central nervous system relapse. A second attempt of chemotherapy failed and the patient died two months later.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Cellules dendritiques
/
Tumeurs du système nerveux central
/
Tumeurs hématologiques
Limites du sujet:
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2017
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Hospital Dr. Guillermo Grant Benavente/CL
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