Study of the protective effect of dexamethasone on cisplatin-induced ototoxicity in rats
Acta cir. bras
;
32(10): 873-880, Oct. 2017. graf
Article
Dans Anglais
| LILACS
| ID: biblio-886168
ABSTRACT
Abstract Purpose:
To evaluate the ability of dexamethasone to protect against cisplatin (CDDP)-induced ototoxicity.Methods:
Male Wistar rats were divided into the following three groups 1) Control (C) 6 animals received intraperitoneal (IP) saline solution, 8 ml/kg/day for four days; 2) C + CDDP 11 animals received 8 ml/kg/day of IP saline and, 90 min after saline administration, 8 mg/kg/day of IP CDDP for four days; and 3) DEXA15 + CDDP 11 animals received IP dexamethasone 15 mg/kg/day and, 90 min after dexamethasone administration, received 8 mg/kg/day of IP CDDP for four days.Results:
It was found that dexamethasone did not protect against weight loss in CDDP-exposed animals. The mortality rate was comparable with that previously reported in the literature. The auditory threshold of animals in the DEXA15 + CDDP group was not significantly altered after exposure to CDDP. The stria vascularis of animals in the DEXA15 + CDDP group was partially preserved after CDDP exposure.Conclusions:
Dexamethasone at the dose of 15 mg/kg/day partially protected against CDDP-induced ototoxicity, based on functional evaluation by brainstem evoked response audiontry (BERA) and morphological evaluation by optical microscopy. However, dexamethasone did not protect against systemic toxicity.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Seuil auditif
/
Dexaméthasone
/
Cisplatine
/
Cochlée
/
Agents protecteurs
/
Antinéoplasiques
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2017
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal do Ceará/BR
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