Differences between NMRI and DBA/2J mice in the development of somites and susceptibility to methylnitrosourea-induced skeleton anomalies
An. acad. bras. ciênc
;
89(1,supl): 635-647, May. 2017. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-886672
ABSTRACT
ABSTRACT The development of DBA/2J mouse strain embryos is nearly 12 h - or 6 somite pairs - delayed as compared to the outbred NMRI mouse embryos of the same age on gestation days (GD) 8-12. To evaluate inter-strain differences in susceptibility to teratogens, dams were treated with methylnitrosourea (MNU, 5 mg/kg body weight i.p.) on defined gestation days (NMRI GD 9, 91/2 or 10; DBA/2J GD 10 or 101/2). Skeletal anomalies produced by MNU on both mouse strains varied with the GD of treatment. The pattern of anomalies produced by MNU on a given GD markedly differed between the two mouse strains, yet they were similar -with a few exceptions- when exposures at equivalent embryonic stages are compared. Findings from this study indicated that strain-dependent differences in the developmental stage of mouse embryos of the same gestational age occur, a possibility that has been often neglected when inter-strain differences in susceptibility to developmental toxicants are interpreted.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Squelette
/
Tératogènes
/
Somites
/
Développement embryonnaire
/
Embryon de mammifère
/
1-Méthyl-1-nitroso-urée
Limites du sujet:
Animaux
/
Grossesse
langue:
Anglais
Texte intégral:
An. acad. bras. ciênc
Thème du journal:
Science
Année:
2017
Type:
Article
Pays d'affiliation:
Allemagne
Institution/Pays d'affiliation:
Charité - Universitätsmedizin Berlin/DE
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