Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
An. acad. bras. ciênc
;
89(3): 1369-1379, July-Sept. 2017. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-886755
ABSTRACT
ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Triterpènes
/
Lamiaceae
/
Triterpènes pentacycliques
/
Fabaceae
/
Antinéoplasiques
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
An. acad. bras. ciênc
Thème du journal:
Science
Année:
2017
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal da Bahia/BR
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