Chromoblastomycosis: tissue modifications during itraconazole treatment
An. bras. dermatol
;
92(4): 478-483, July-Aug. 2017. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-886989
ABSTRACT
Abstract Background:
Histological and mycological changes during itraconazole use have not been totally established in chromoblastomycosis.Objectives:
To evaluate tissue modifications in chromoblastomycosis carriers under itraconazole treatment.Methods:
A histological retrospective study of 20 cases of chromoblastomycosis seen at the university hospital at the south of Brazil, during itraconazole 400 mg daily treatment. Patients were classified into two groups plaque or tumor lesions, and underwent periodic evaluations every four months during three years. Hematoxylin-eosin stain was used to analyze epidermal modifications, inflammatory infiltrate and fibrosis, and Fontana-Masson stain for parasite evaluation.Results:
Fontana-Masson stain was superior to hematoxylin-eosin stain in fungal count in the epidermis (mean difference=0.14; p<0.05). The most distinct mycosis tissue responses were registered in the dermis. Epidermal thinning, granulomatous infiltrate decrease or disappearance, fibrosis increase and quantitative/morphological changes occurred during treatment. Studylimitations:
Patients could not be located to have their current skin condition examined.Conclusion:
Parasitic and tissue changes verified in this study can reflect the parasite-host dynamics under itraconazole action.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Peau
/
Chromoblastomycose
/
Itraconazole
/
Maladies des agriculteurs
/
Antifongiques
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
An. bras. dermatol
Thème du journal:
Dermatologie
Année:
2017
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Positivo/BR
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