Episodic angioedema associated with eosinophilia
An. bras. dermatol
;
92(4): 534-536, July-Aug. 2017. graf
Article
Dans Anglais
| LILACS
| ID: biblio-887014
ABSTRACT
Abstract We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years. During the episode, her white blood cell count increased to 47.7×109/L with 89.9% eosinophils, followed by elevated serum level of IL-5, IgE, IgM, and LDH. Histopathology showed perivascular eosinophilic infiltration and diffuse eosinophilic infiltration throughout the dermis. Possible causes of hypereosinophilia and eosinophilic infiltration of vital organs were ruled out. We also tested the FIP1L1/PDGFRa and ETV6/PDGFRb fusion gene to exclude the possibility of myeloid and lymphatic vessel neoplasms. The patient was treated with methylprednisolone and discharged with an oral prednisolone taper, which resulted in complete remission of the edema and normalization of peripheral blood eosinophil count, serum IL-5 level, IgE, IgM, and LDH.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Éosinophilie
/
Angioedème
Type d'étude:
Facteurs de risque
Limites du sujet:
Enfant
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
An. bras. dermatol
Thème du journal:
Dermatologie
Année:
2017
Type:
Article
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
Nanjing University School of Medicine/CN
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