Prepubertal and postpubertal vitiligo: a multivariate comparative study in 375 patients
An. bras. dermatol
;
92(6): 811-815, Nov.-Dec. 2017. tab
Article
Dans Anglais
| LILACS
| ID: biblio-887118
ABSTRACT
Abstract Background:
The onset of vitiligo during childhood is common. Limited data exist that compare the clinical associations of prepubertal and postpubertal vitiligo in Arabs.Objective:
To compare the clinical profile of pre and postpubertal onset vitiligo.Methods:
A cross-sectional observational study was conducted. The Vitiligo European Task Force questionnaire was completed for each patient.Results:
A total of 375 patients were included; 199 had postpubertal vitiligo (>12 years), and 176 had prepubertal onset vitiligo (<12years). There were more females in the prepubertal group (49%) than in the postpubertal group (29%), p-value <0.001. The prepubertal group has had more involvement than the postpubertal group (45% vs 30%, p=0.004). Only 8 cases of segmental vitiligo were observed; five were observed in the prepubertal group of patients. Female gender (OR=2.3; 95% CI1.5, 3.5), presence of halo nevus (OR=2.2; 95% CI1.1, 4.4) and face involvement (OR=1.9; 95% CI1.2, 2.9) were positively associated with prepubertal vitiligo. Stress, as an onset factor, was positively associated (OR=0.51; 95% CI0.3, 0.8) with postpubertal onset vitiligo. Studylimitations:
A possible selection bias toward more severe vitiligo cases can be a limitation, because the study was conducted in a clinic specialized in vitiligo. Moreover, a likelihood of false recall bias cannot be excluded.Conclusions:
Our data present clinical evidence that vitiligo behaves mostly the same way in the prepubertal group as in the postpubertal group. However, female over-representation, more face involvement and more halo nevi were observed in prepubertal vitiligo, while stress was more prevalent as an aggravating factor in postpubertal vitiligo patients.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Vitiligo
/
Puberté
Type d'étude:
Étude observationnelle
/
Étude de prévalence
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Enfant
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
An. bras. dermatol
Thème du journal:
Dermatologie
Année:
2017
Type:
Article
Pays d'affiliation:
Arabie saoudite
Institution/Pays d'affiliation:
King Saud University/SA
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