Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist?
Arch. endocrinol. metab. (Online)
; 61(3): 276-281, May-June 2017. tab, graf
Article
de En
| LILACS
| ID: biblio-887561
Bibliothèque responsable:
BR1.1
ABSTRACT
ABSTRACT Objective The objective of this study is to evaluate the performance of mathematical models used in non-invasive diagnosis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients to determine when the patient needs to be referred to a hepatologist. Subjects and methods Patients referred by endocrinologists to the liver outpatient departments in two hospitals in Curitiba, Brazil, over a 72-month period were analyzed. The results calculated using the APRI, FIB 4, FORNS and NAFLD Fibrosis Score non-invasive liver fibrosis assessment models were analyzed and compared with histological staging of this population. Results Sixty-seven patients with NAFLD were analyzed. Forty-two of them (62.68%) were female, mean age was 54.76 (±9.63) years, mean body mass index 31.42 (±5.64) and 59 (88.05%) of the 67 cases had glucose intolerance or diabetes. A diagnosis of steatohepatitis was made in 45 (76.27%) of the 59 biopsied patients, and advanced liver fibrosis (stages 3 and 4) was diagnosed in 18 (26.86%) of the 67 patients in the study population. The FIB 4 and NAFLD Fibrosis Score models had a high negative predictive value (93.48% and 93.61%, respectively) in patients with severe liver fibrosis (stages 3 and 4). Conclusion In conclusion, use of the FIB 4 and NAFLD Fibrosis Score models in NAFLD patients allows a diagnosis of severe liver disease to be excluded.
Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Orientation vers un spécialiste
/
Stéatose hépatique non alcoolique
/
Endocrinologues
/
Gastro-entérologues
/
Cirrhose du foie
Type d'étude:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
Limites du sujet:
Female
/
Humans
/
Male
langue:
En
Texte intégral:
Arch. endocrinol. metab. (Online)
Thème du journal:
ENDOCRINOLOGIA
/
METABOLISMO
Année:
2017
Type:
Article