Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes
Arch. endocrinol. metab. (Online)
;
61(5): 455-459, Sept.-Oct. 2017. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-887598
ABSTRACT
ABSTRACT Objective To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Subjects and methods Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Results Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Conclusion Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Protéines de liaison au calcium
/
Diabète gestationnel
/
Protéines de liaison à l'ADN
/
Protéines de tissu nerveux
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Grossesse
langue:
Anglais
Texte intégral:
Arch. endocrinol. metab. (Online)
Thème du journal:
Endocrinologie
/
Métabolisme
Année:
2017
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Bolu University/TR
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