Expression of miR-155, miR-146a, and miR-326 in T1D patients from Chile: relationship with autoimmunity and inflammatory markers
Arch. endocrinol. metab. (Online)
; 62(1): 34-40, Jan.-Feb. 2018. tab, graf
Article
Dans En
| LILACS
| ID: biblio-887623
Responsable en Bibliothèque :
BR1.1
ABSTRACT
ABSTRACT Objective The aim of this research was to analyze the expression profile of miR-155, miR-146a, and miR-326 in peripheral blood mononuclear cells (PBMC) of 47 patients with type 1 diabetes mellitus (T1D) and 39 control subjects, as well as the possible association with autoimmune or inflammatory markers. Subjects and methods Expression profile of miRs by means of qPCR using TaqMan probes. Autoantibodies and inflammatory markers by ELISA. Statistical analysis using bivariate correlation. Results The analysis of the results shows an increase in the expression of miR-155 in T1D patients in basal conditions compared to the controls (p < 0.001) and a decreased expression level of miR-326 (p < 0.01) and miR-146a (p < 0.05) compared T1D patients to the controls. miR-155 was the only miRs associated with autoinmmunity (ZnT8) and inflammatory status (vCAM). Conclusion Our data show a possible role of miR-155 related to autoimmunity and inflammation in Chilean patients with T1D.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
MicroARN
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Diabète de type 1
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites du sujet:
Child
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Humans
Pays comme sujet:
America do sul
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Chile
langue:
En
Texte intégral:
Arch. endocrinol. metab. (Online)
Thème du journal:
ENDOCRINOLOGIA
/
METABOLISMO
Année:
2018
Type:
Article