The relationship between of ACE I/D and the MTHFR C677T polymorphisms in the pathophysiology of type 2 diabetes mellitus in a population of Brazilian obese patients
Arch. endocrinol. metab. (Online)
;
62(1): 21-26, Jan.-Feb. 2018. tab
Article
Dans Anglais
| LILACS
| ID: biblio-887636
ABSTRACT
ABSTRACT Objectives This study aimed to evaluate the frequencies of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) and methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphisms in obese patients with and without type 2 diabetes mellitus (T2DM). Subjects and methods These polymorphisms were analyzed by polymerase chain reaction in 125 patients with obesity, 47 (T2DM) and 78 (Control Group). Results No significant difference was found on comparing the T2DM and Control Groups in respect to the genotypic frequencies of the polymorphisms - (II 13.3% vs. 12.0%; ID 37.8% vs. 37.3; DD 48.9% vs. 50.7%; CC 36.2% vs. 39.0%; CT 46.8% vs. 49.3%; TT 17.0% vs. 11.7%), and alleles (I 32.2% vs. 30.7%; D 67.8% vs. 69.3%; C 59.6% vs. 63.6%; T 40.4% vs. 36.4%) and their synergisms in the pathophysiology of T2DM. On analyzing the T2DM Group, there were no significant differences in the presence of complications. In this population of Brazilian obese patients, no correlation was found between the ACE and MTHFR polymorphisms in the development of T2DM. Conclusion Analyzing only the group with diabetes, there was also no relationship between these polymorphisms and comorbidities.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Polymorphisme génétique
/
Peptidyl-Dipeptidase A
/
Methylenetetrahydrofolate reductase (NADPH2)
/
Diabète de type 2
/
Obésité
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Arch. endocrinol. metab. (Online)
Thème du journal:
Endocrinologie
/
Métabolisme
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual Paulista "Júlio de Mesquita Filho"/BR
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