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The relationship between of ACE I/D and the MTHFR C677T polymorphisms in the pathophysiology of type 2 diabetes mellitus in a population of Brazilian obese patients
Pirozzi, Flavio Fontes; Belini Junior, Edis; Okumura, Jessika Viviani; Salvarani, Mariana; Bonini-Domingos, Claudia Regina; Ruiz, Milton Artur.
  • Pirozzi, Flavio Fontes; Universidade Estadual Paulista "Júlio de Mesquita Filho". Departamento de Biologia. São José do Rio Preto. BR
  • Belini Junior, Edis; Universidade Estadual Paulista "Júlio de Mesquita Filho". Departamento de Biologia. São José do Rio Preto. BR
  • Okumura, Jessika Viviani; Universidade Estadual Paulista "Júlio de Mesquita Filho". Departamento de Biologia. São José do Rio Preto. BR
  • Salvarani, Mariana; Universidade Estadual Paulista "Júlio de Mesquita Filho". Departamento de Biologia. São José do Rio Preto. BR
  • Bonini-Domingos, Claudia Regina; Universidade Estadual Paulista "Júlio de Mesquita Filho". Departamento de Biologia. São José do Rio Preto. BR
  • Ruiz, Milton Artur; Universidade Estadual Paulista "Júlio de Mesquita Filho". Departamento de Biologia. São José do Rio Preto. BR
Arch. endocrinol. metab. (Online) ; 62(1): 21-26, Jan.-Feb. 2018. tab
Article Dans Anglais | LILACS | ID: biblio-887636
ABSTRACT
ABSTRACT Objectives This study aimed to evaluate the frequencies of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) and methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphisms in obese patients with and without type 2 diabetes mellitus (T2DM). Subjects and methods These polymorphisms were analyzed by polymerase chain reaction in 125 patients with obesity, 47 (T2DM) and 78 (Control Group). Results No significant difference was found on comparing the T2DM and Control Groups in respect to the genotypic frequencies of the polymorphisms - (II 13.3% vs. 12.0%; ID 37.8% vs. 37.3; DD 48.9% vs. 50.7%; CC 36.2% vs. 39.0%; CT 46.8% vs. 49.3%; TT 17.0% vs. 11.7%), and alleles (I 32.2% vs. 30.7%; D 67.8% vs. 69.3%; C 59.6% vs. 63.6%; T 40.4% vs. 36.4%) and their synergisms in the pathophysiology of T2DM. On analyzing the T2DM Group, there were no significant differences in the presence of complications. In this population of Brazilian obese patients, no correlation was found between the ACE and MTHFR polymorphisms in the development of T2DM. Conclusion Analyzing only the group with diabetes, there was also no relationship between these polymorphisms and comorbidities.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Polymorphisme génétique / Peptidyl-Dipeptidase A / Methylenetetrahydrofolate reductase (NADPH2) / Diabète de type 2 / Obésité Type d'étude: Etude d'étiologie / Étude observationnelle / Facteurs de risque Limites du sujet: Adolescent / Adulte / Adulte très âgé / Femelle / Humains / Mâle Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Arch. endocrinol. metab. (Online) Thème du journal: Endocrinologie / Métabolisme Année: 2018 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Estadual Paulista "Júlio de Mesquita Filho"/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Polymorphisme génétique / Peptidyl-Dipeptidase A / Methylenetetrahydrofolate reductase (NADPH2) / Diabète de type 2 / Obésité Type d'étude: Etude d'étiologie / Étude observationnelle / Facteurs de risque Limites du sujet: Adolescent / Adulte / Adulte très âgé / Femelle / Humains / Mâle Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Arch. endocrinol. metab. (Online) Thème du journal: Endocrinologie / Métabolisme Année: 2018 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Estadual Paulista "Júlio de Mesquita Filho"/BR