Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis
Braz. j. med. biol. res
;
50(10): e6148, 2017. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-888939
ABSTRACT
This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polymorphisms (SNPs) of ADAM33 (rs511898, rs2280092, rs3918396, rs528557, rs2853209, rs44707, rs2280091 and rs2280089) were analyzed based on several models including the allele, codominant, recessive and dominant models. The results showed that the ADAM33 rs2280091 polymorphism in all four genetic models was associated with an increased risk of childhood asthma. Positive associations were also found between the polymorphisms rs2280090, rs2787094, rs44707 and rs528557 and childhood asthma in some genetic models. This meta-analysis suggested that ADAM33 polymorphisms rs2280091, rs2280090, rs2787094, rs44707 and rs528557 were significantly associated with a high risk of childhood asthma.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Asthme
/
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
/
Protéines ADAM
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
/
Revues systématiques évaluées
Limites du sujet:
Enfant
/
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2017
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
Guangzhou Medical University/CN
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