Potential benefit of (-)-epigallocatechin-3-gallate for macrovascular complications in diabetes
Braz. j. med. biol. res
;
50(10): e6511, 2017. tab
Article
Dans Anglais
| LILACS
| ID: biblio-888942
ABSTRACT
Vascular problems are the most common complications in diabetes. Substantial evidence from epidemiological and pathophysiological studies show that hyperglycemia is a major risk factor for macrovascular complications in patients with diabetes. (-)-Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, is known to exert a variety of cardiovascular beneficial effects. The protective effects of EGCG in diabetes are also evident. However, whether EGCG is beneficial against macrovascular complications that occur in diabetes remains unknown. Our previous studies demonstrated that treatment of EGCG inhibits high glucose-induced vascular smooth muscle cell proliferation and suppresses high glucose-mediated vascular inflammation in human umbilical vein endothelial cells. Therefore, we hypothesize that EGCG might be an effective potential candidate to reduce the macrovascular complications in diabetes.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Catéchine
/
Agents protecteurs
/
Angiopathies diabétiques
Type d'étude:
Facteurs de risque
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2017
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
Daping Hospital, Third Military Medical University/CN
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