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Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children
Melo, Silvia V.; Agnes, Grasiela; Vitolo, Márcia R.; Mattevi, Vanessa S.; Campagnolo, Paula D.B.; Almeida, Silvana.
  • Melo, Silvia V.; Universidade Federal de Ciências da Saúde de Porto Alegre. Laboratório de Biologia Molecular. Porto Alegre. BR
  • Agnes, Grasiela; Universidade Federal de Ciências da Saúde de Porto Alegre. Laboratório de Biologia Molecular. Porto Alegre. BR
  • Vitolo, Márcia R.; Universidade Federal de Ciências da Saúde de Porto Alegre. Laboratório de Biologia Molecular. Porto Alegre. BR
  • Mattevi, Vanessa S.; Universidade Federal de Ciências da Saúde de Porto Alegre. Laboratório de Biologia Molecular. Porto Alegre. BR
  • Campagnolo, Paula D.B.; Universidade Federal de Ciências da Saúde de Porto Alegre. Laboratório de Biologia Molecular. Porto Alegre. BR
  • Almeida, Silvana; Universidade Federal de Ciências da Saúde de Porto Alegre. Laboratório de Biologia Molecular. Porto Alegre. BR
Genet. mol. biol ; 40(2): 415-420, Apr.-June 2017. tab
Article Dans Anglais | LILACS | ID: biblio-892412
ABSTRACT
Abstract Taste perception plays a key role in determining individual food preferences and dietary habits and may influence nutritional status. This study aimed to investigate the association of TAS1R2 (Ile191Val - rs35874116) and TAS1R3 (-1266 C/T - rs35744813) variants with food intake and nutritional status in children followed from birth until 7.7 years old. The nutritional status and food intake data of 312 children were collected at three developmental stages (1, 3.9 and 7.7 years old). DNA was extracted from blood samples and the polymorphisms were analyzed by real-time polymerase chain reactions (qPCR) using hydrolysis probes as the detection method. Food intake and nutritional status were compared among individuals with different single nucleotide polymorphism (SNP) genotypes. At 3.9 years old, children homozygous (Val/Val) for the TAS1R2 Ile191Val polymorphism ingested less sugar and sugar-dense foods than children who were *Ile carriers. This finding demonstrated that a genetic variant of the T1R2 taste receptor is associated with the intake of different amounts of high sugar-content foods in childhood. This association may provide new perspectives for studying dietary patterns and nutritional status in childhood.


Texte intégral: Disponible Indice: LILAS (Amériques) Type d'étude: Facteurs de risque langue: Anglais Texte intégral: Genet. mol. biol Thème du journal: Génétique Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Type d'étude: Facteurs de risque langue: Anglais Texte intégral: Genet. mol. biol Thème du journal: Génétique Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre/BR