Cytotoxic activity in cutaneous leishmaniasis
Mem. Inst. Oswaldo Cruz
;
112(11): 733-740, Nov. 2017. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-894850
ABSTRACT
Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Cellules tueuses naturelles
/
Lymphocytes T cytotoxiques
/
Leishmaniose cutanée
/
Lymphocytes T CD8/
/
Cytotoxicité immunologique
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2017
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal da Bahia/BR
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