A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge
Rev. Soc. Bras. Med. Trop
;
50(5): 709-711, Sept.-Oct. 2017. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-897014
ABSTRACT
Abstract The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis. The altered immunological responses caused by anti-TNF treatment made the diagnosis challenging. Clinicians should bear this in mind and, if suspected, treatment should be initiated immediately.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Arthrite juvénile
/
Méningite tuberculeuse
/
Inhibiteurs du facteur de nécrose tumorale
/
Antituberculeux
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Adolescent
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2017
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Medical School of Ege University/TR
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