Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
Rev. Soc. Bras. Med. Trop
;
51(1): 111-114, Jan.-Feb. 2018. graf
Article
Dans Anglais
| LILACS
| ID: biblio-897041
ABSTRACT
Abstract The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process. Together with P. lutzii, P. brasiliensis appears to be involved in severe cases of PCM.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Paracoccidioides
/
Blastomycose sud-américaine
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Fiocruz/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS