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Relationship between high red cell distribution width and systemic inflammatory response syndrome after extracorporeal circulation
Seth, Harsh Sateesh; Mishra, Prashant; Khandekar, Jayant V; Raut, Chaitanya; Mohapatra, Chandan Kumar Ray; Ammannaya, Ganesh Kumar K; Saini, Jaskaran Singh; Shah, Vaibhav.
  • Seth, Harsh Sateesh; Lokmanya Tilak Municipal Medical College and General Hospital. Department of Cardiovascular and Thoracic Surgery. IN
  • Mishra, Prashant; Lokmanya Tilak Municipal Medical College and General Hospital. Department of Cardiovascular and Thoracic Surgery. IN
  • Khandekar, Jayant V; Lokmanya Tilak Municipal Medical College and General Hospital. Department of Cardiovascular and Thoracic Surgery. IN
  • Raut, Chaitanya; Lokmanya Tilak Municipal Medical College and General Hospital. Department of Cardiovascular and Thoracic Surgery. IN
  • Mohapatra, Chandan Kumar Ray; Lokmanya Tilak Municipal Medical College and General Hospital. Department of Cardiovascular and Thoracic Surgery. IN
  • Ammannaya, Ganesh Kumar K; Lokmanya Tilak Municipal Medical College and General Hospital. Department of Cardiovascular and Thoracic Surgery. IN
  • Saini, Jaskaran Singh; Lokmanya Tilak Municipal Medical College and General Hospital. Department of Cardiovascular and Thoracic Surgery. IN
  • Shah, Vaibhav; Lokmanya Tilak Municipal Medical College and General Hospital. Department of Cardiovascular and Thoracic Surgery. IN
Rev. bras. cir. cardiovasc ; 32(4): 288-294, July-Aug. 2017. tab, graf
Article Dans Anglais | LILACS | ID: biblio-897927
ABSTRACT
Abstract

Objective:

Cardiac surgical operations involving extracorporeal circulation may develop severe inflammatory response. This severe inflammatory response syndrome (SIRS) is usually associated with poor outcome with no predictive marker. Red cell distribution width (RDW) is a routine hematological marker with a role in inflammation. We aim to determine the relationship between RDW and SIRS through our study.

Methods:

A total of 1250 patients who underwent cardiac surgery with extracorporeal circulation were retrospectively analyzed out of which 26 fell into the SIRS criteria and 26 consecutive control patients were taken. RDW, preoperative clinical data, operative time and postoperative data were compared between SIRS and control groups.

Results:

The demographic profile of the patients was similar. RDW was significantly higher in the SIRS versus control group (15.5±2.0 vs. 13.03±1.90), respectively with P value <0.0001. There was significant mortality in the SIRS group, 20 (76.92%) as compared to 2 (7.6%) in control group with a P value of <0.005. Multiple logistic regression analysis revealed that there was significant association with high RDW and development of SIRS after extracorporeal circulation (OR for RDW levels exceeding 13.5%; 95% CI 1.0-1.2; P<0.05).

Conclusion:

Increased RDW was significantly associated with increased risk of SIRS after extracorporeal circulation. Thus, RDW can act as a useful tool to predict SIRS in patients undergoing cardiac surgery with extracorporeal circulation. Hence, more aggressive measures can be taken in patients with high RDW to prevent postoperative morbidity and mortality.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Complications postopératoires / Syndrome de réponse inflammatoire généralisée / Index érythrocytaires / Circulation extracorporelle Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adulte très âgé / Femelle / Humains / Mâle langue: Anglais Texte intégral: Rev. bras. cir. cardiovasc Thème du journal: Cardiologie / Chirurgie générale Année: 2017 Type: Article Pays d'affiliation: Inde Institution/Pays d'affiliation: Lokmanya Tilak Municipal Medical College and General Hospital/IN

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Complications postopératoires / Syndrome de réponse inflammatoire généralisée / Index érythrocytaires / Circulation extracorporelle Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adulte très âgé / Femelle / Humains / Mâle langue: Anglais Texte intégral: Rev. bras. cir. cardiovasc Thème du journal: Cardiologie / Chirurgie générale Année: 2017 Type: Article Pays d'affiliation: Inde Institution/Pays d'affiliation: Lokmanya Tilak Municipal Medical College and General Hospital/IN