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TBARS and BDNF levels in newborns exposed to crack/cocaine during pregnancy: a comparative study
Mardini, Victor; Rohde, Luis A; Ceresér, Keila M; Gubert, Carolina M; Silva, Emily G da; Xavier, Fernando; Parcianello, Rodrigo; Röhsig, Liane M; Pechansky, Flávio; Szobot, Claudia M.
  • Mardini, Victor; Hospital de Clínicas de Porto Alegre. Serviço de Psiquiatria da Infância e Adolescência (SPIA). RS. BR
  • Rohde, Luis A; Hospital de Clínicas de Porto Alegre. Serviço de Psiquiatria da Infância e Adolescência (SPIA). RS. BR
  • Ceresér, Keila M; Hospital de Clínicas de Porto Alegre. Serviço de Psiquiatria da Infância e Adolescência (SPIA). RS. BR
  • Gubert, Carolina M; Hospital de Clínicas de Porto Alegre. Serviço de Psiquiatria da Infância e Adolescência (SPIA). RS. BR
  • Silva, Emily G da; Hospital de Clínicas de Porto Alegre. Serviço de Psiquiatria da Infância e Adolescência (SPIA). RS. BR
  • Xavier, Fernando; Hospital de Clínicas de Porto Alegre. Serviço de Psiquiatria da Infância e Adolescência (SPIA). RS. BR
  • Parcianello, Rodrigo; Hospital de Clínicas de Porto Alegre. Serviço de Psiquiatria da Infância e Adolescência (SPIA). RS. BR
  • Röhsig, Liane M; Hospital de Clínicas de Porto Alegre. Serviço de Psiquiatria da Infância e Adolescência (SPIA). RS. BR
  • Pechansky, Flávio; Hospital de Clínicas de Porto Alegre. Serviço de Psiquiatria da Infância e Adolescência (SPIA). RS. BR
  • Szobot, Claudia M; Hospital de Clínicas de Porto Alegre. Serviço de Psiquiatria da Infância e Adolescência (SPIA). RS. BR
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 39(3): 263-266, July-Sept. 2017. tab
Article Dans Anglais | LILACS | ID: biblio-899353
ABSTRACT

Objectives:

To compare levels of a marker of lipid peroxidation (thiobarbituric acid reactive substances, TBARS) and brain-derived neurotrophic factor (BDNF) in umbilical cord blood (UCB) between newborns exposed to crack/cocaine in utero (exposed newborns [EN], n=57) and non-exposed newborns (NEN, n=99), as well as in maternal peripheral blood at delivery.

Methods:

This was a cross-sectional study. Potential confounders, including perinatal parameters, psychopathology, and use of other substances, were assessed.

Results:

After adjusting for potential confounders, adjusted mean BDNF was significantly higher in EN (3.86 ng/mL, 95% confidence interval [95%CI] 2.29-5.43) than in NEN (0.85 ng/mL, 95%CI 0.47-1.23; p < 0.001; Cohen effect size 1.12), and significantly lower in crack/cocaine mothers than in control mothers (4.03 ng/mL, 95%CI 2.87-5.18 vs. 6.67 ng/mL, 95%CI 5.60-7.74; p = 0.006). The adjusted mean TBARS level was significantly lower in EN (63.97 µM MDA, 95%CI 39.43-88.50) than NEN (177.04 µM MDA, 95%CI 140.93-213.14; p < 0.001; effect size = 0.84), with no difference between mother groups (p = 0.86).

Conclusions:

The changes in TBARS levels observed in EN suggest that fetuses exposed to cocaine mobilize endogenous antioxidant routes since very early stages of development. The increase in BDNF levels in EN might indicate changes in fetal development, whereas the changes in BDNF levels in mothers provide evidence of the complex metabolic processes involved in drug use during pregnancy.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Crack / Substances réactives à l&apos;acide thiobarbiturique / Facteur neurotrophique dérivé du cerveau / Sang foetal Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Adolescent / Adulte / Femelle / Humains / Nouveau-né / Grossesse langue: Anglais Texte intégral: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Thème du journal: Psychiatrie Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Hospital de Clínicas de Porto Alegre/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Crack / Substances réactives à l&apos;acide thiobarbiturique / Facteur neurotrophique dérivé du cerveau / Sang foetal Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Adolescent / Adulte / Femelle / Humains / Nouveau-né / Grossesse langue: Anglais Texte intégral: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Thème du journal: Psychiatrie Année: 2017 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Hospital de Clínicas de Porto Alegre/BR