Huge recurrent gastric neuroendocrine tumor: a second-line chemotherapeutic dilemma
Autops. Case Rep
;
8(1): e2018005, Jan.-Mar. 2018. ilus
Article
Dans Anglais
| LILACS
| ID: biblio-905466
ABSTRACT
Chemotherapy is considered "state of the art" for the treatment of poorly differentiated neuroendocrine neoplasms. Unfortunately, there is no standard effective post-first-line treatment for relapsing high-grade gastroenteropancreatic neuroendocrine neoplasms. We report the case of a patient with a gastric neuroendocrine carcinoma stage IV, with massive gastrointestinal bleeding at diagnosis. After the first line of platin-based chemotherapy a major tumoral response was documented, but the patient relapsed after 4 months. A second line of chemotherapy treatment was given, with the FOLFOX regimen, and the patient has been free of progression for almost 2 years. There is no second-line standard treatment accepted for this type of carcinoma, but 5-fluorouracil combined with oxaliplatin showed interesting antitumor activity.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Composés organiques du platine
/
Tumeurs de l'estomac
/
Carcinomes
/
Protocoles de polychimiothérapie antinéoplasique
/
Tumeurs neuroendocrines
/
Fluorouracil
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Autops. Case Rep
Thème du journal:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Année:
2018
Type:
Article
Pays d'affiliation:
Portugal
/
Espagne
Institution/Pays d'affiliation:
Centro Hospitalar S. Joao/PT
/
Hospital Universitario Ramon y Cajal/ES
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