Clinical features and preventive therapies of radiation-induced xerostomia in head and neck cancer patient: a literature review
Appl. cancer res
;
37: 1-8, 2017. ilus
Article
Dans Anglais
| LILACS, Inca
| ID: biblio-915109
ABSTRACT
Xerostomia or dry mouth is one of the most common and disturbing adverse effects following radiotherapy for head and neck cancer (HNC). This complication strongly increases the risk for dental caries, difficulties with chewing, swallowing and sleep disorders with significant impact on patients' quality of life. Current treatment approaches of xerostomia are often difficult and bring in many cases no substantial relief for the patient. This paper discusses the clinical features and current knowledge of xerostomia prevention in order to evaluate the real possibilities of reducing the incidence and severity of this complication in HNC patients. Salivary gland cytoprotectants (amifostine), muscarinic agonist stimulation (pilocarpine and bethanechol), salivary gland-sparing radiation technique (intensity-modulated radiotherapy- IMRT), surgical relocation of the submandibular gland, intraoral stent and stem cell transplantation are promising techniques that are discussed in this study (AU)
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Pilocarpine
/
Radiothérapie
/
Glandes salivaires
/
Glande submandibulaire
/
Littérature de revue comme sujet
/
Transplantation de cellules souches
/
Prévention des Maladies
/
Tumeurs de la tête et du cou
Type d'étude:
Revues systématiques évaluées
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Appl. cancer res
Thème du journal:
Tumeurs
Année:
2017
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
A.C.Camargo Cancer Center/BR
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