Current challenges in the therapeutic use of induced pluripotent stem cells (iPSCs) in cancer therapy
Appl. cancer res
;
37: 1-8, 2017. ilus
Article
Dans Anglais
| LILACS, Inca
| ID: biblio-915112
ABSTRACT
Induced Pluripotent Stem Cells (iPSCs) technology has catapulted the field of stem-cell biology through ectopic expression of reprogramming factors. Ever since its discovery, the potential of iPSCs has been explored by many scientists to unravel the molecular mechanism responsible for cancer initiation and progression. Besides modeling cancer, the further applications of this technology includes high-throughput drug screening, epigenetic reprogramming of cancer cell state to normal, immunotherapy and regenerative cell therapies. Here, we review the current challenges on clinical applications of iPSCs with respect to understanding cancer and personalizing treatment for the disease (AU)
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Cellules souches
/
Cellules souches pluripotentes
/
Mécanismes moléculaires de l'action pharmacologique
/
Tumeurs
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Appl. cancer res
Thème du journal:
Tumeurs
Année:
2017
Type:
Article
Pays d'affiliation:
Inde
Institution/Pays d'affiliation:
Jaslok Hospital & Research Centre/IN
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