Interleukin-4 protects from chemotherapy-induced peripheral neuropathy in mice modal via the stimulation of IL-4/STAT6 signaling
Acta cir. bras
;
33(6): 491-498, June 2018. graf
Article
Dans Anglais
| LILACS
| ID: biblio-949359
ABSTRACT
Abstract Purpose:
To investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy.Methods:
The mouse model of vincristine-induced peripheral neuropathy and interleukin (IL)-4 knockout mice were utilized to investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Vincristine induced increased sensitivity to mechanical stimulation was measured by von Frey hair test 7 and 14 days after intraperitoneal administration of 0.1 mg/kg vincristine in mice. Relative expression levels of cytokines were detected by quantitative real-time PCR. STAT6 expression following vincristine treatment was assessed with western blotting.Results:
We discovered that IL-4/STAT6 signaling was down-regulated in vincristine-treated mice. Deletion of IL-4 in mice increased the sensitivity to mechanical allodynia. IL-4 knockout mice also produced more pro-inflammatory cytokines, including IL-1β and TNF-α. Notably, co-administration of exogenous recombination IL-4 significantly prevented vincristine-induced mechanical allodynia.Conclusion:
Anti-inflammatory cytokine IL-4 protects rodent model from vincristine-induced peripheral neuropathy via the stimulation of IL-4/STAT6 signaling and inhibition of the pro-inflammatory cytokines.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Vincristine
/
Interleukine-4
/
Neuropathies périphériques
/
Facteur de transcription STAT-6
/
Anti-inflammatoires
/
Antinéoplasiques d'origine végétale
Type d'étude:
Études d'évaluation
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2018
Type:
Article
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
Traditional Chinese Medicine Hospital/CN
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