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Immunhistochemical analysis of Nuclear Factor Kappa Beta expression in etiopathogenesis of ovarian tumors
Yilmaz, Ercan; Gul, Mehmet; Melekoglu, Rauf; Koleli, Isil.
  • Yilmaz, Ercan; Inonu University. Faculty of Medicine. Department of Obstetrics and Gynecology. Malatya. TR
  • Gul, Mehmet; Inonu University. Faculty of Medicine. Department of Histology and Embriyology. Malatya. TR
  • Melekoglu, Rauf; Inonu University. Faculty of Medicine. Department of Obstetrics and Gynecology. Malatya. TR
  • Koleli, Isil; Inonu University. Faculty of Medicine. Department of Obstetrics and Gynecology. Malatya. TR
Acta cir. bras ; 33(7): 641-650, July 2018. tab, graf
Article Dans Anglais | LILACS | ID: biblio-949369
ABSTRACT
Abstract

Purpose:

To investigate the place of the transcription factor nuclear kappa B (NF-kB), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma.

Methods:

NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kB expression in the ovarian tissue, the H-score method. H-score = ∑ Pi (i+1), where ''Pi'' is the percentage of stained cells in each intensity category (0-100%) and ''i'' is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3).

Results:

It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p<0.005).

Conclusions:

Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Tumeurs de l&apos;ovaire / Facteur de transcription NF-kappa B / Cystadénome séreux / Cystadénocarcinome séreux Type d'étude: Etude diagnostique Limites du sujet: Adulte / Adulte très âgé / Aged80 / Femelle / Humains langue: Anglais Texte intégral: Acta cir. bras Thème du journal: Chirurgie générale / Procedimentos Cir£rgicos Operat¢rios Année: 2018 Type: Article Pays d'affiliation: Turquie Institution/Pays d'affiliation: Inonu University/TR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Tumeurs de l&apos;ovaire / Facteur de transcription NF-kappa B / Cystadénome séreux / Cystadénocarcinome séreux Type d'étude: Etude diagnostique Limites du sujet: Adulte / Adulte très âgé / Aged80 / Femelle / Humains langue: Anglais Texte intégral: Acta cir. bras Thème du journal: Chirurgie générale / Procedimentos Cir£rgicos Operat¢rios Année: 2018 Type: Article Pays d'affiliation: Turquie Institution/Pays d'affiliation: Inonu University/TR