Genetic variants associated with neurodegenerative Alzheimer disease in natural models
Biol. Res
;
49: 1-9, 2016. graf, tab
Article
Dans Anglais
| LILACS
| ID: biblio-950841
ABSTRACT
The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Variation génétique
/
Modèles animaux de maladie humaine
/
Maladie d'Alzheimer
Type d'étude:
Facteurs de risque
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Biol. Res
Thème du journal:
Biologie
Année:
2016
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Universidad de Valparaiso/CL
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