Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy
Braz. j. med. biol. res
;
49(2): e5080, 2016. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-951656
ABSTRACT
We aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-positive patients who met the treatment indication (controls). The GS group was divided into GS group 1 and GS group 2. All groups were administered bismuth potassium citrate (220 mg), esomeprazole (20 mg), amoxicillin (1.0 g), and furazolidone (100 mg) twice daily for 14 days. GS group 1 maintained a left lateral horizontal position for 30 min after dosing. H. pylori was detected using rapid urease testing and histologic examination of gastric mucosa before and 3 months after therapy. Mucosal histologic manifestations were evaluated using visual analog scales of the updated Sydney System. GS group 1 had a higher prevalence of eradication than the GS group 2 (intention-to-treat [ITT] P=0.025; per-protocol [PP] P=0.030), and the control group had a similar prevalence. GS group 2 had a lower prevalence of eradication than controls (ITT P=0.006; PP P=0.626). Scores for chronic inflammation and activity declined significantly (P<0.001) 3 months after treatment, whereas those for atrophy and intestinal metaplasia showed no significant change. Prevalence of adverse reactions was similar among groups during therapy (P=0.939). A bismuth-containing quadruple therapy regimen plus postural change after dosing appears to be a relatively safe, effective, economical, and practical method for H. pylori eradication in gastrectomized patients.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Helicobacter pylori
/
Infections à Helicobacter
/
Moignon gastrique
/
Gastrectomie
/
Antibactériens
Type d'étude:
Essai clinique contrôlé
/
Guide de pratique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2016
Type:
Article
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
Fudan University/CN
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