Elastin increases biofilm and extracellular matrix production of Aspergillus fumigatus
Braz. j. microbiol
;
49(3): 675-682, July-Sept. 2018. graf
Article
Dans Anglais
| LILACS
| ID: biblio-951801
ABSTRACT
Abstract Aspergillus fumigatus is an opportunistic saprobe fungus that accounts for 90% of cases of pulmonary aspergillosis in immunosuppressed patients and is known for its angiotropism. When it reaches the respiratory tract, A. fumigatus interacts with structural components and blood vessels of the lungs, such as elastin. To understand the effect of this structural component, we examined the effect of elastin on the production and development of the biofilm of A. fumigatus. In RPMI containing 10 mg/mL of elastin, a significant increase (absorbance p < 0.0001; dry weight p < 0.0001) in the production of biofilm was observed in comparison to when RPMI was used alone, reaching a maximum growth of 18.8 mg (dry weight) of biofilm in 72 h. In addition, elastin stimulates the production (p = 0.0042) of extracellular matrix (ECM) and decreases (p = 0.005) the hydrophobicity during the development of the biofilm. These results suggest that elastin plays an important role in the growth of A. fumigatus and that it participates in the formation of thick biofilm.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Aspergillose
/
Aspergillus fumigatus
/
Élastine
/
Biofilms
/
Matrice extracellulaire
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Braz. j. microbiol
Thème du journal:
Microbiologie
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal de Pernambuco/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS