A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
Braz. J. Pharm. Sci. (Online)
;
54(2): e17183, 2018. tab, graf, ilus
Article
Dans Anglais
| LILACS
| ID: biblio-951934
ABSTRACT
ABSTRACT Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the self-assembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and exhibit a pH-triggered release
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Libération de médicament
/
Concentration en ions d'hydrogène
langue:
Anglais
Texte intégral:
Braz. J. Pharm. Sci. (Online)
Thème du journal:
Farmacologia
/
Teraputica
/
Toxicologia
Année:
2018
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Colombie
Institution/Pays d'affiliation:
Universidad Nacional de Colombia/CO
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