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Effective method for the detection of piroxicam in human plasma using HPLC
Calvo, Adriana Maria; Prado, Mariel Tavares de Oliveira; Dionísio, Thiago José; Marques, Maria Paula; Brozoski, Daniel Thomas; Lanchote, Vera Lúcia; Faria, Flávio Augusto Cardoso; Santos, Carlos Ferreira.
  • Calvo, Adriana Maria; Universidade de São Paulo. Bauru School of Dentistry. Department of Biological Sciences. Bauru. BR
  • Prado, Mariel Tavares de Oliveira; Universidade de São Paulo. Bauru School of Dentistry. Department of Biological Sciences. Bauru. BR
  • Dionísio, Thiago José; Universidade de São Paulo. Bauru School of Dentistry. Department of Biological Sciences. Bauru. BR
  • Marques, Maria Paula; Universidade de São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of Clinical. Ribeirão Preto. BR
  • Brozoski, Daniel Thomas; Universidade de São Paulo. Bauru School of Dentistry. Department of Biological Sciences. Bauru. BR
  • Lanchote, Vera Lúcia; Universidade de São Paulo. Bauru School of Dentistry. Department of Biological Sciences. Bauru. BR
  • Faria, Flávio Augusto Cardoso; Universidade de São Paulo. Bauru School of Dentistry. Department of Biological Sciences. Bauru. BR
  • Santos, Carlos Ferreira; Universidade de São Paulo. Bauru School of Dentistry. Department of Biological Sciences. Bauru. BR
Braz. oral res. (Online) ; 30(1): e58, 2016. tab, graf
Article Dans Anglais | LILACS | ID: biblio-952014
ABSTRACT
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by the general population to alleviate inflammation and pain after oral surgeries. Piroxicam is among the most commonly used NSAIDs and excels in controlling pain, swelling, trismus and other common symptoms of inflammation. This study aimed to evaluate different concentrations of piroxicam and its major metabolite, 5'-hydroxypiroxicam, in human plasma samples over time using high performance liquid chromatography (HPLC) after liquid-liquid extraction. Briefly, 10 volunteers participated in this study after approval by the Ethics Committee of Bauru School of Dentistry, Universidade de São Paulo - USP, Brazil. Volunteers received a single dose oral of piroxicam (20 mg) and had blood collected at various times following an established protocol. The methodology of liquid-liquid extraction was effective for determining concentrations of piroxicam in plasma using HPLC in 10 out of 10 volunteers while 5'-hydroxypiroxicam was only detected in 2 out of 10 volunteers.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Piroxicam / Anti-inflammatoires non stéroïdiens / Chromatographie en phase liquide à haute performance / Extraction liquide-liquide Type d'étude: Etude diagnostique / Études d'évaluation Limites du sujet: Humains langue: Anglais Texte intégral: Braz. oral res. (Online) Thème du journal: Dentisterie Année: 2016 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de São Paulo/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Piroxicam / Anti-inflammatoires non stéroïdiens / Chromatographie en phase liquide à haute performance / Extraction liquide-liquide Type d'étude: Etude diagnostique / Études d'évaluation Limites du sujet: Humains langue: Anglais Texte intégral: Braz. oral res. (Online) Thème du journal: Dentisterie Année: 2016 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de São Paulo/BR