Effective method for the detection of piroxicam in human plasma using HPLC
Braz. oral res. (Online)
;
30(1): e58, 2016. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-952014
ABSTRACT
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by the general population to alleviate inflammation and pain after oral surgeries. Piroxicam is among the most commonly used NSAIDs and excels in controlling pain, swelling, trismus and other common symptoms of inflammation. This study aimed to evaluate different concentrations of piroxicam and its major metabolite, 5'-hydroxypiroxicam, in human plasma samples over time using high performance liquid chromatography (HPLC) after liquid-liquid extraction. Briefly, 10 volunteers participated in this study after approval by the Ethics Committee of Bauru School of Dentistry, Universidade de São Paulo - USP, Brazil. Volunteers received a single dose oral of piroxicam (20 mg) and had blood collected at various times following an established protocol. The methodology of liquid-liquid extraction was effective for determining concentrations of piroxicam in plasma using HPLC in 10 out of 10 volunteers while 5'-hydroxypiroxicam was only detected in 2 out of 10 volunteers.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Piroxicam
/
Anti-inflammatoires non stéroïdiens
/
Chromatographie en phase liquide à haute performance
/
Extraction liquide-liquide
Type d'étude:
Etude diagnostique
/
Études d'évaluation
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Braz. oral res. (Online)
Thème du journal:
Dentisterie
Année:
2016
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de São Paulo/BR
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