Experimental osteonecrosis: development of a model in rodents administered alendronate
Braz. oral res. (Online)
;
30(1): e99, 2016. graf
Article
Dans Anglais
| LILACS
| ID: biblio-952039
ABSTRACT
Abstract The main objective of this study was to cause bisphosphonate-related osteonecrosis of the jaws to develop in a rodent model. Adult male Holtzman rats were assigned to one of two experimental groups to receive alendronate (AL; 1 mg/kg/week; n = 6) or saline solution (CTL; n = 6). After 60 days of drug therapy, all animals were subjected to first lower molar extraction, and 28 days later, animals were euthanized. All rats treated with alendronate developed osteonecrosis, presenting as ulcers and necrotic bone, associated with a significant infection process, especially at the inter-alveolar septum area and crestal regions. The degree of vascularization, the levels of C-telopeptide cross-linked collagen type I and bone-specific alkaline phosphatase, as well as the bone volume were significantly reduced in these animals. Furthermore, on radiographic analysis, animals treated with alendronate presented evident sclerosis of the lamina dura of the lower first molar alveolar socket associated with decreased radiographic density in this area. These findings indicate that the protocol developed in the present study opens new perspectives and could be a good starting model for future property design.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Alendronate
/
Modèles animaux de maladie humaine
/
Agents de maintien de la densité osseuse
/
Ostéonécrose de la mâchoire associée aux biphosphonates
Type d'étude:
Guide de pratique
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. oral res. (Online)
Thème du journal:
Dentisterie
Année:
2016
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Centro Universitário do Estado do Pará/BR
/
Universidade Estadual Paulista/BR
/
Universidade Federal do Rio de Janeiro/BR
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