Lipoxygenase inhibitors flavonoids from Cyperus rotundus aerial parts
Rev. bras. farmacogn
;
28(3): 320-324, May-June 2018. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-958873
ABSTRACT
ABSTRACT Cyperus rotundus L. (Suada, Sueda, family Cyperaceae) is vastly spread in several world's subtropical and tropical regions. It had variable traditional uses and bioactivities. A new flavonol derivative cyperaflavoside (myricetin 3,3',5'-trimethyl ether 7-O-β-D-glucopyranoside) and five flavonoids vitexin, orientin, cinaroside, quercetin 3-O-β-D-glucopyranoside, and myrcetin 3-O-β-D-glucopyranoside were separated from the methanolic extract of C. rotundus aerial parts. Their structures were verified based on UV, IR, NMR (1D and 2D), HRESIMS, and comparison with literature. All metabolites were assessed for their 5-lipoxygenase inhibitory potential. All compounds possessed 5-lipoxygenase inhibitory potentials with IC50s 5.1, 4.5, 5.9, 4.0, 3.7, and 2.3 µM, respectively, in comparison to indomethacin (IC50 0.98 µM). These results supported the traditional uses of C. rotundus in treating inflammation and its related symptoms.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
langue:
Anglais
Texte intégral:
Rev. bras. farmacogn
Thème du journal:
Pharmacie
Année:
2018
Type:
Article
Pays d'affiliation:
Arabie saoudite
Institution/Pays d'affiliation:
King Abdulaziz University/SA
/
Taibah University/SA
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